SUBOXONE sublSuboxone is a prescription medication used to treat opioid dependence and addiction. It combines buprenorphine, a partial opioid agonist that reduces withdrawal symptoms and cravings, with naloxone, an opioid antagonist that helps prevent misuse. Suboxone works by activating opioid receptors in the brain to ease withdrawal without producing the intense high associated with opioids, making it an effective tool in medication-assisted treatment (MAT). It is typically administered as a sublingual film or tablet and is part of a comprehensive treatment plan including counseling and behavioral therapy.ingual film is indicated for treatment of opioid dependence. SUBOXONE sublingual film should be used as part of a complete treatment plan that includes counseling and psychosocial support. SUBOXONE sublingual film is administered sublingually or buccally as a single daily dose.