Amaryl is a brand name for the medication glimepiride, which is used to treat type 2 diabetes by helping the pancreas produce more insulin and lowering blood sugar levels. It belongs to a class of drugs called sulfonylureas. Amaryl is typically taken orally once a day, preferably with breakfast or the first main meal. It’s important to follow your doctor’s instructions and monitor blood sugar levels regularly while taking Amaryl to avoid complications. Common side effects may include hypoglycemia (low blood sugar), weight gain, and gastrointestinal issues.